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Mixing & Blending Equipment for Buffer Prep Solutions

Buffer Solutions have a useful property of remaining at a stable pH when a strong acid or base is added to the system. Each Buffer Solution has a maximum amount of acid/base it can absorb which is called its Buffer Capacity. Buffer Solutions are made with an aqueous mixture of a weak acid and it congregate base or a weak base with it congregate acid.

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Optimize Your Buffer Prep with White Mountain Process

Proper mixing is critical in producing buffer solution. First, the salt form needs to be completely dissolved and disassociated for all of its ions to be available to the equilibrium system. Next, the weak acid or base needs to be homogeneous in the solution for the proper equilibrium to be achieved. The pH usually needs to be adjusted to the final system’s pH level to be effective so good mixing is important during this step to ensure the correct additions are made for the final preparation.

Buffer Preparation, or “buffer prep” is a very common application in biopharma. Portable mixtanks or larger scale blending vessels are used to make up a buffer solution used in downstream feed for bioreactors.

Potential WMProcess mixers that could be used:

  • SANITARY TOP ENTRY MIXER – for open top tank a C Clamp Mount mixer is typical, or for closed sealed vessels a TC mount agitator is common – mixers can be used on sanitary stainless vessels or FDA/USP VI poly tanks
  • HIGH SHEAR MIXER– for rapid dispersion and dissolving on salts, powders, and pellets
  • BOTTOM ENTRY MAGMIXER – Low shear gear drive mixers, medium shear direct drive bottom mag mixers, and high shear mag drive agitators can be used for buffer make up. WMProcess can accommodate mag drive mixers on either stainless tanks or poly vessels.

Mixing Equipment
For Bioprocess Engineers

WMP has been providing “mixing solutions” to industry professionals for more than two decades.

1 Liter – 10,000 Gallon Mix Tank Sizes Available

Stainless – Poly PE – PP, PVDF, PTFE, Titanium, Hastelloy C, & More

Mixers and agitators

We offer a large assortment of agitator, motor, and mount types – contact us today to request a quote.

  • Autoclave and Carboy Style Mixers
  • Sanitary Mixers for Aseptic Mixing Applications
  • Industrial Top Entry Mixers
  • Bottom Entry Mixers
  • Side Entry Mixers
  • Lab Mixers
  • GMP and High Purity Agitators
  • Corrosion Resistant Mixers and Mixtanks
  • High Viscosity Mixers
  • High Shear Mixers

Agitator Options

We can spec your process equipment with many agitator options – propeller, impeller, & more

Industrial Mixing Equipment 

Built to Your Specs

Sanitary Mix Tanks & Vessels
Sanitary Vessel/Mixer/Valve Packages
Sanitary Mechanical Seals
Industrial Agitators
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Specialty Mixers

Discover the benefits of world-class engineering and our White Mountain Peak-performance Team. We’re committed to making your job easier. Ask about our proprietary squeal-less dry-running mechanical seal for controlled-humidity environments. It’s blissfully quiet in performance!



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