Single-Use Mixers Bioprocess & High Purity - Sanitary Mixing Tanks

Single-Use Bioprocess Mixing Systems

White Mountain Process manufactures disposable and single-use mixing and blending systems for biotech, biopharma, and high purity manufacturers.

Single-Use Sanitary Mixing System Options

Mixer and agitator drives with various output speeds and motor configurations
Variety of “wetted” materials available, including 316Lss, USP VI PE/PP/PVDF, Hast C, Titanium, and other exotic materials
Variety of mixer connections for open containers and closed/sealed bags
Custom designs for any single use mixing application
Lab mixing to pilot scale blending to full scale agitation

CLICK HERE for Sealed Carboy Mixer System Drawing

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Contact Our Process Experts Today For A Free Quote

Types of Single Use Mixing Systems

We manufacture single use mixers in a wide range of designs. Open and closed systems, suited for many specific applications.

Single Use Bottom Entry Mixers
Single use mixers using traditional disposable bags, with a bottom entry mixer design which is guaranteed to not shed or fail. There are no moving parts on this blender design which provides more uptime, zero chance of failure, and no worries on particulate shedding which can be an issue on traditional plastic magmixer designs.

WMProcess bottom mount mixer design is a new innovative Single Use Mixing System. Using a single use pumphead, this disposable blending equipment becomes a multi purpose bioprocessing system for:
- Single use mixing of solutions by recirculation, without rotating wetted mixer parts.
- Integrated filling and emptying of the bag
- Post mixing processes like sterile filtration, TFF, flow through chromatography and others
- Optional integration of in line single use sensors (including sensors for pH, conductivity, temperature, and UV)
- Optional integration of a heat exchanger for cooling and heating of the media
- Excellent disposable mixing system for buffer, media, and sterile processing
Principle: the QuattroMix Single-Use Mixing System has an inlet and outlet port which both are connected to a pumping device. Through the outlet port the media will be pumped out of the bag, circulates through the pump (and other possible post-mixing processes) and will be pumped back in the bag through 16 nozzles with a smooth fluid stream.

WMP Mixing Bags are available from 10liters to 2000liters.

Mechanical Drives

Mechanical Drives

With shaft mounted pitched-blade turbine style impellers

Because of their powerful coupling (direct drive) and high torque delivery, these mixers are appropriate for liquid/liquid operations as well as powder/liquid operations. They are available both open and closed, and can be mounted on the top or bottom. They function well in automated systems with online sensors, and are applicable for buffer and/or media preparation, virus inactivation, to control pH, end-stage formulation and also, filling.

Paddle Mixers

Paddle Mixers

This closed-style mixer provides vertical paddles which rotate, creating radial flow patterns. Other than the paddle, they have no moving parts. Therefore, they’re often preferred for particle sensitive operations like aseptic manufacturing lacking final sterilization filters. They are the mixer of choice for any final aseptic operation, or for purposes such as cell culture media, suspension and re-suspension in the course of purification, the preparation of chromatography sorbent slurry, etc.

Stir/Rod Wand Mixers

Levitating & Magnetic Mixers

Levitating & Magnetic Mixers

Similar in some ways to paddle mixers, these closed style mixers also use vertical paddles. They function well in large scale liquid/solid and liquid/liquid applications such as buffer/media prep. Magnetic mixers are useful in heavy-duty applications because they provide the power required for heavy loads such as in the dissolution of dry powder media cultures. Levitating mixers are especially well suited for applications in which extreme cleanliness is critical. Later stage downstream processing, aseptic vaccine production when final sterile filtration and/or particle removal is unavailable, therapeutic cell media prep, etc. are all good examples. The lack of moving parts, bearings, shafts, etc. within the mixing bag eliminates friction that might otherwise possibly create unwanted particles.

Orbital Shakers

Orbital Shakers from White Mountain Process

Our Orbital Shakers are perfect for blending buffers, proteins, chromatography slurries and a great choice for mixing with either carboys or single use bags.

Orbital Lab Shakers are known for their ability to provide low shear and gentle blending, to more vigorous shaking and mixing action. Shakers are heavy duty and robust, easy to use, and extremely effective at mixing very quickly and uniformly.

Orbital Shakers typical options we can provide:

Biopharma ready, complete documentation packages, IQ/OQ optional, FAT testing optional.
Heavy Duty Large Volume Mixing and Small Volume blending
Fixed Speed or Variable Speed / High or Low Speed
Variable Speed digital display with digital countdown timer
Temperature controlled top plate typical
Explosion Proof and Hazardous Duty motors available
Remote Control Operation available
All Stainless Steel Models
Incubator High Humidity and CO2 gassed models

Single Use Jet Mixers

Single-Use Jet Mixers

With Gamma Radiated Disposable Single-Use Bags

Another closed system that employs suction which draws liquid from its top that it then expels via directional ports. Single-use jet mixers are user friendly, portable and economical, and work well for clean operations such as the homogenization of fluids, or the re-homogenization or re-suspension of previously stored fluids.

A single use mixer need not be complicated. It is possible for such a mixer to be as simplistic as a two dimensional container on a rocker table or a disposable 3D liner placed inside of a mixing tank. Single use mixers graduate in complexity, particularly within closed systems that employ mechanical drives. Regardless of their sophistication, they all serve the same purposes. Above all else, single use mixers increase efficiency, keep costs low, and are integral to the production of a quality product.

Single Use Bioreactors

SINGLE USE BIOREACTORS

Regular

• Touchscreen interface / CellMaker software

• Accurate mass flow controller Air / O regulation

• Pressure sensor allows automatic shutdown in case of over pressure

• Front rotameter for visual control of gas flow

• Compatible with both 8L and 50L Enclosures

• Optional automatic feed addition via external pump

PLUS

• All the benefits of the Regular system, plus:

• Fitted with pH meter allowing pH monitoring and automatic control via dual acid/base pump and CO2

• Fitted with Dissolved Oxygen meter allowing pO2 monitoring and automatic control using O2

Our specially designed CellMaker airlift single-use bioreactors have been created to perfectly suit your system and your application. Single-use bags are easily replaced within minutes for a fast turnaround so you can start on your next process.

Sterile bags are fitted into the enclosure and the contents are agitated by bubbles created by a customizable influx of gasses. Our robust system is designed without any moving parts, eliminating the chance of mechanical failure. In addition, gentle agitation from our bubbles reduces the risk of cell shearing usually associated with agitated mixing impellers. Single use disposable mixing bags are available in sizes 8 Liters and 50 Liters to suit your enclosure, and provide working volumes of 3L to 8L, and 10L to 50L.

Our CellMaker Regular Bioreactors are compatible for use with our CellMaker Regular Controller and CellMaker Plus Controller. While our CellMaker Plus Bioreactors are designed for use with our CellMaker Plus Controller only. These bags contain a sensor for measuring dissolved oxygen and a pH port making these bags ideal for providing precise control over more challenging processes.

Single-Use Mixer Features

FOR DISPOSABLE MIXING WITH ASEPTIC SEALED DISPOSABLE MIXER & CONTAINER

Single use top entry mixer drive blending system
Sealed sterile containers
Disposable mixer and container setup
Gamma radiated / sterilized mixing bags
Full cert package
Bottom entry mixing systems with NO moving parts (zero shedding, no particulate generation, eliminate CIP/SIP, no cross contamination between batches.

Benefits of Single Use Mixing

SOME ADVANTAGES OF USING A SINGLE USE MIXER INCLUDE:

Single use mixers tend to be user friendly
Decreased risk of cross-contamination
Smaller financial investment
Ends cleaning validation and sterilization concerns
Faster production times
Increased accuracy
Convenient and readily available storage
Reduction in personnel costs
Ready to use
Adjustable output
Elimination of need for tank and impeller cleaning

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Mixing Equipment
For Bioprocess Engineers

WMP has been providing “mixing solutions” to industry professionals for more than two decades.

1 Liter – 10,000 Gallon Mix Tank Sizes Available

Stainless – Poly PE – PP, PVDF, PTFE, Titanium, Hastelloy C, & More

Mixers and agitators

We offer a large assortment of agitator, motor, and mount types – contact us today to request a quote.

Autoclave and Carboy Style Mixers
Sanitary Mixers for Aseptic Mixing Applications
Industrial Top Entry Mixers
Bottom Entry Mixers
Side Entry Mixers
Lab Mixers
GMP and High Purity Agitators
Corrosion Resistant Mixers and Mixtanks
High Viscosity Mixers
High Shear Mixers

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Agitator Options

We can spec your process equipment with many agitator options – propeller, impeller, & more

Industrial Mixing Equipment

Built to Your Specs

Sanitary Mix Tanks & Vessels

Sanitary Vessel/Mixer/Valve Packages

Sanitary Mechanical Seals

Industrial Agitators

Sanitary Mixers

Custom Mixing Packages

Lab Production-Scale Equipment

Specialty Mixers

Discover the benefits of world-class engineering and our White Mountain Peak-performance Team. We’re committed to making your job easier. Ask about our proprietary squeal-less dry-running mechanical seal for controlled-humidity environments. It’s blissfully quiet in performance!